Two sample MR report
ADK_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0556753 | 0.1064358 | 0.6370903 |
| Weighted median | 5 | -0.0537824 | 0.0208519 | 0.0099014 |
| Inverse variance weighted | 5 | -0.0579221 | 0.0171242 | 0.0007184 |
| Simple mode | 5 | -0.0729840 | 0.0310192 | 0.0782698 |
| Weighted mode | 5 | -0.0415021 | 0.0290475 | 0.2262732 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2941179 | 3 | 0.9611309 |
| Inverse variance weighted | 1.4634834 | 4 | 0.8330896 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1126168 | 0.1041425 | 0.3587045 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.85e-05 | 0 | TRUE | 0.3731326 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
